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Table 7 The combined effects of smoking and cardiovascular risk indicators on cardiovascular disease risk assessment

From: Investigating the interplay of smoking, cardiovascular risk factors, and overall cardiovascular disease risk: NHANES analysis 2011–2018

Exposure

Non-adjusted

OR (95%CI) P-value

Adjust I

OR (95%CI) P-value

Adjust II

OR (95%CI) P-value

Non-smoker, low WHTR

Ref

Ref

Ref

 Non-smoker, high WHTR

2.49 (2.04, 3.05) < 0.0001

1.72 (1.38, 2.14) < 0.0001

1.22 (0.95, 1.56) 0.1215

 Smoker, low WHTR

1.67 (1.27, 2.18) 0.0002

2.37 (1.76, 3.19) < 0.0001

2.64 (1.90, 3.67) < 0.0001

 Smoker, high WHTR

2.72 (2.05, 3.60) < 0.0001

3.20 (2.35, 4.35) < 0.0001

2.51 (1.77, 3.58) < 0.0001

Non-smoker, low VAI

Ref

Ref

Ref

 Non-smoker, high VAI

1.61 (1.33, 1.95) < 0.0001

1.58 (1.28, 1.95) < 0.0001

1.34 (1.06, 1.70) 0.0158

 Smoker, low VAI

1.19 (0.93, 1.54) 0.1675

1.87 (1.41, 2.48) < 0.0001

2.20 (1.61, 3.01) < 0.0001

 Smoker, high VAI

1.92 (1.48, 2.49) < 0.0001

3.15 (2.35, 4.21) < 0.0001

3.05 (2.20, 4.22) < 0.0001

Non-smoker, low ABSI

Ref

Ref

Ref

 Non-smoker, high ABSI

3.76 (3.01, 4.69) < 0.0001

1.50 (1.17, 1.92) 0.0012

1.33 (1.02, 1.74) 0.0324

 Smoker, low ABSI

1.11 (0.76, 1.62) 0.5843

1.74 (1.16, 2.61) 0.0069

2.19 (1.43, 3.36) 0.0003

 Smoker, high ABSI

4.69 (3.60, 6.11) < 0.0001

2.94 (2.21, 3.92) < 0.0001

2.98 (2.17, 4.10) < 0.0001

Non-smoker, low CI

Ref

Ref

Ref

 Non-smoker, high CI

4.25 (3.38, 5.35) < 0.0001

1.88 (1.47, 2.41) < 0.0001

1.44 (1.10, 1.89) 0.0087

 Smoker, low CI

1.27 (0.87, 1.85) 0.2084

1.81 (1.22, 2.69) 0.0035

2.25 (1.48, 3.44) 0.0002

 Smoker, high CI

5.41 (4.11, 7.13) < 0.0001

3.78 (2.81, 5.09) < 0.0001

3.28 (2.36, 4.57) < 0.0001

Non-smoker, low TyG

Ref

Ref

Ref

 Non-smoker, high TyG

1.61 (1.33, 1.95) < 0.0001

1.31 (1.06, 1.61) 0.0115

1.04 (0.82, 1.31) 0.7714

 Smoker, low TyG

1.17 (0.88, 1.56) 0.2879

1.91 (1.38, 2.63) < 0.0001

2.21 (1.55, 3.17) < 0.0001

 Smoker, high TyG

1.94 (1.51, 2.48) < 0.0001

2.57 (1.95, 3.38) < 0.0001

2.40 (1.76, 3.26) < 0.0001

Non-smoker, low NEUT

Ref

Ref

Ref

 Non-smoker, high NEUT

1.88 (1.55, 2.28) < 0.0001

1.73 (1.40, 2.13) < 0.0001

1.44 (1.15, 1.81) 0.0016

 Smoker, low NEUT

1.04 (0.76, 1.42) 0.8275

1.65 (1.17, 2.32) 0.0043

2.05 (1.41, 2.96) 0.0001

 Smoker, high NEUT

2.09 (1.66, 2.64) < 0.0001

3.16 (2.44, 4.10) < 0.0001

3.13 (2.34, 4.20) < 0.0001

Non-smoker, low NLR

Ref

Ref

Ref

 Non-smoker, high NLR

2.21 (1.83, 2.68) < 0.0001

1.58 (1.28, 1.95) < 0.0001

1.46 (1.16, 1.84) 0.0011

 Smoker, low NLR

1.42 (1.10, 1.84) 0.0079

2.21 (1.66, 2.95) < 0.0001

2.70 (1.97, 3.69) < 0.0001

 Smoker, high NLR

2.26 (1.74, 2.95) < 0.0001

2.72 (2.03, 3.65) < 0.0001

2.75 (1.97, 3.83) < 0.0001

Non-smoker, low MPV

Ref

Ref

Ref

 Non-smoker, high MPV

1.31 (1.08, 1.58) 0.0057

1.32 (1.07, 1.62) 0.0082

1.27 (1.02, 1.59) 0.0348

 Smoker, low MPV

1.35 (1.05, 1.72) 0.0194

2.24 (1.70, 2.96) < 0.0001

2.64 (1.94, 3.60) < 0.0001

 Smoker, high MPV

1.44 (1.10, 1.89) 0.0089

2.30 (1.70, 3.11) < 0.0001

2.47 (1.77, 3.45) < 0.0001

  1. Non-adjusted model adjust for: None
  2. Adjust I model adjust for: Sex; Age; Race
  3. Adjust II model adjust for: Sex; Age; Race; A; ALT; AST; BUN; CR; TB; UA; Alcohol; Anti-platelet; β-blockers; ACEI/ARB; Statin; Diuretic; Anticoagulant