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Table 3 Relationship between common cardiovascular risk factors and cardiovascular disease risk

From: Investigating the interplay of smoking, cardiovascular risk factors, and overall cardiovascular disease risk: NHANES analysis 2011–2018

Exposure

Non-adjusted

OR (95%CI) P-value

Adjust I

OR (95%CI) P-value

Adjust II

OR (95%CI) P-value

Waist

1.03 (1.02, 1.03) < 0.0001

1.02 (1.02, 1.03) < 0.0001

1.01 (1.00, 1.02) 0.0027

Waist (quartile)

 Q1

Ref

Ref

Ref

 Q2

1.86 (1.39, 2.49) < 0.0001

1.13 (0.83, 1.55) 0.4273

0.94 (0.67, 1.32) 0.7207

 Q3

2.55 (1.93, 3.37) < 0.0001

1.30 (0.96, 1.76) 0.0886

0.99 (0.71, 1.39) 0.9700

 Q4

3.93 (3.01, 5.13) < 0.0001

2.22 (1.66, 2.96) < 0.0001

1.42 (1.02, 1.98) 0.0404

P for trend

< 0.0001

< 0.0001

0.0064

TG

1.26 (1.14, 1.39) < 0.0001

1.29 (1.15, 1.45) < 0.0001

1.17 (1.02, 1.34) 0.0233

TG (quartile)

 Q1

Ref

Ref

Ref

 Q2

1.44 (1.12, 1.85) 0.0043

1.17 (0.89, 1.53) 0.2637

0.96 (0.71, 1.29) 0.7766

 Q3

1.64 (1.28, 2.10) < 0.0001

1.32 (1.01, 1.72) 0.0458

1.02 (0.76, 1.38) 0.8958

 Q4

1.83 (1.43, 2.32) < 0.0001

1.59 (1.22, 2.07) 0.0006

1.17 (0.86, 1.59) 0.3145

P for trend

< 0.0001

0.0003

0.2230

HDL-c

0.58 (0.47, 0.72) < 0.0001

0.40 (0.32, 0.52) < 0.0001

0.59 (0.45, 0.76) < 0.0001

HDL-c (quartile)

 Q1

Ref

Ref

Ref

 Q2

0.73 (0.59, 0.91) 0.0040

0.66 (0.52, 0.84) 0.0006

0.73 (0.56, 0.95) 0.0184

 Q3

0.53 (0.42, 0.66) < 0.0001

0.43 (0.33, 0.56) < 0.0001

0.56 (0.42, 0.75) 0.0001

 Q4

0.56 (0.45, 0.70) < 0.0001

0.37 (0.28, 0.48) < 0.0001

0.54 (0.40, 0.72) < 0.0001

P for trend

< 0.0001

< 0.0001

< 0.0001

HTN

 No

Ref

Ref

Ref

 Yes

5.40 (4.46, 6.54) < 0.0001

2.41 (1.95, 2.96) < 0.0001

1.57 (1.23, 1.99) 0.0003

DM

 No

Ref

Ref

Ref

 Yes

3.68 (3.11, 4.37) < 0.0001

2.14 (1.78, 2.58) < 0.0001

1.40 (1.14, 1.74) 0.0017

  1. Non-adjusted model adjust for: None
  2. Adjust I model adjust for: Sex; Age; Race
  3. Adjust II model adjust for: Sex; Age; Race; A; ALT; AST; BUN; CR; TB; UA; Alcohol; Smoke; Anti-platelet; β-blockers; ACEI/ARB; Statin; Diuretic; Anticoagulant