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Table 2 Exploring the associations between serum cotinine levels and cardiovascular disease risk

From: Investigating the interplay of smoking, cardiovascular risk factors, and overall cardiovascular disease risk: NHANES analysis 2011–2018

Exposure

Non-adjusted

OR (95%CI) P-value

Adjust I

OR (95%CI) P-value

Adjust II

OR (95%CI) P-value

Log Cotinine

1.05 (1.01, 1.10) 0.0273

1.21 (1.14, 1.27) < 0.0001

1.25 (1.18, 1.33) < 0.0001

Log Cotinine (quartile)

 Q1

Ref

Ref

Ref

 Q2

0.81 (0.63, 1.04) 0.0979

0.97 (0.74, 1.28) 0.8393

0.94 (0.69, 1.27) 0.6733

 Q3

0.89 (0.71, 1.10) 0.2854

1.25 (0.99, 1.60) 0.0654

1.16 (0.89, 1.52) 0.2683

 Q4

1.06 (0.86, 1.31) 0.5698

2.07 (1.63, 2.64) < 0.0001

2.33 (1.77, 3.07) < 0.0001

P for trend

0.6010

< 0.0001

< 0.0001

  1. Non-adjusted model adjust for: None
  2. Adjust I model adjust for: Sex; Age; Race
  3. Adjust II model adjust for: Sex; Age; Race; SBP; DBP; BMI; Waist; HDL-c; TG; LDL-c; TC; HbA1c; FPG; A; ALT; AST; BUN; CR; TB; UA; Alcohol; HTN; DM; CKD; Anti-platelet; β-blockers; ACEI/ARB; Statin; Diuretic; Anticoagulant