Fig. 5
The expression of Notch1 and Jagged-1 in VSMCs. 1: Control group, 2: AngII (10− 6mol/L) group, 3: AngII (10− 6mol/L) + Entresto (10− 5mol/L) group. (4A) Entresto was used for 1 h before Ang II stimulation for 24 h, and then the expression of Notch1 and Jagged-1 at mRNA level was detected by qRT-PCR. (4B) Entresto was used for 1 h before Ang II stimulation for 24 h, and then the expression of Notch1 and Jagged-1 at the protein level was observed by Western Blot. (4C) This is the quantization diagram, mean ± SEM (n = 3), a: p < 0.05, compared with the control group, b: p < 0.05, compared with Ang II group