Fig. 4

A meta-regression analysis of variables of interest affecting changes in left ventricular ejection fraction. A dichotomous a priori subgroup analysis was performed in a trial examining the effect of hydrogel combination therapy on ejection fraction. Point estimates at each subgroup level are pooled effect estimates for ejection fraction in the hydrogel combination therapy group compared with the hydrogel-only therapy group. a. Hydrogel type, b. Combination therapy, c. Sex, d. Small animal model, e. Time of treatment, f. Durations, g. MQS and h. Animal model were subjected to subgroup analysis. MQS = Hyland Methodological Quality