Fig. 2

miR-26a-5p overactivated autophagy leading to NLRP3 inflammasome activation in a PE-induced cardiomyocyte hypertrophy model. (A): The mRNA expression of miR-26a-5p after mimic and inhibitor intervened cardiomyocytes. (B-E): The mRNA expression of miR-26a-5p, ACS, NLRP3, and Caspase-1 was detected in PE-induced cardiac hypertrophy by RT-qPCR. (F-L): Western blotting detected the protein expression of miR-26a-5p, LC3, beclin-1, p62, ACS, NLRP3, and Caspase-1 in PE-induced cardiac hypertrophy. (*: p-value < 0.05; **: p-value < 0.01; ***: p-value < 0.001.)