Fig. 2
From: Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study
Effect of each cannabis use-associated SNP on risk of CAD (A) or IS (B) and when using a stringent threshold for SNPs’ selection for CAD (C) or IS (D). Meta-analysis of the association of genetically instrumented use of cannabis and risk of CAD for the 63 single-nucleotide polymorphisms (SNPs) (A) and of IS for the 64 SNPs (B). The second meta-analysis shows results when using 5 SNPs which surpassed the conventional genome-wide significance threshold for genome-wide association with lifetime cannabis use (p-value < 5 × 10−8) for CAD (C) and for IS (D). Odds ratios (OR) and 95% confidence intervals (CI) express the risk of event per-1-log unit increase in ever use of cannabis. Meta-analysis uses a fixed effect model