Fig. 1

Meta-analysis of observational studies reporting association between cannabis and atherosclerotic cardiovascular disease. Meta-analysis uses a random-effects model, DerSimonian and Lair methods (DL). Studies are sorted by type of outcome (coronary artery disease, ischemic stroke or global ASCVD analysis). Relatives risk (RR) and 95% confidence intervals (CI) express the risk of ASCVD for “ever use of cannabis” (compared with never use). For additional information on each study, see Additional file 2, Supplementary Table 1. Supplementary Fig. 4 and 5 provide meta-analysis stratified by outcome and type of risk ratio