Table 5 Several findings in this study exhibit substantial innovation in comparison to the published literature
Items | Identification of Hub Genes in AMI Based on Bioinfomatics Analysis | ||
|---|---|---|---|
Our findings | PMID: 37115066 | PMID: 35585822 | |
Years | 2023 | 2023 | 2023 |
Test set | GSE59867 and GSE76591 | GSE95368 | GSE76387 and GSE161427 |
Species/tissue | Human/heart tissue and peripheral blood | Human/peripheral blood | Mice/heart tissue |
Key genes | Key DE-FRG diagnostic biomarker: PIK3CA | S100A9, MAPK3, MAPK1, MMP3, IL17A and HSP90AB1 | Col5a1 |
Validation set | GSE97320, GSE66360 and GSE168149 | - | - |
Verification | qRT-PCR | qRT-PCR | Western blotting |
Mechanism | LncRNA–miRNA–DE-FRG ceRNA network: XIST and OIP5-AS1/miR-216a/PIK3CA | - | - |