Table 2 Haemodynamic data of study patients
From: GLP-1 vasodilatation in humans with coronary artery disease is not adenosine mediated
Variable | GLP-1 group | Saline group | GLP-1 + Theophylline group | Theophylline group | p value |
|---|---|---|---|---|---|
Immediate post PCI | |||||
Baseline | |||||
Heart rate (bpm) | 65.6 (8.9) | 79.3 (32.1) | 68.5 (9.0) | 62.6 (4.6) | 0.21 |
Systolic BP (mmHg) | 131.8 (27.5) | 133.1 (35.9) | 138.3 (20.3) | 133.4 (25.7) | 0.91 |
Diastolic BP (mmHg) | 59.2 (11.3) | 72.3 (17.1) | 64.8 (9.4) | 66.3 (9.9) | 0.14 |
Pa mmHg | 89.7 (16.5) | 97.3 (23.4) | 95.1 (10.8) | 97.6 (14.9) | 0.58 |
Pd mmHg | 84.6 (16.5) | 93.3 (24.1) | 90.5 (9.6) | 94.3 (15.1) | 0.49 |
Pd/Pa | 0.94 (0.04) | 0.95 (0.04) | 0.95 (0.04) | 0.96 (0.04) | 0.51 |
Tmn (s) | 0.87 (0.39) | 0.48 (0.23) | 0.85 (0.79) | 0.48 (0.40) | 0.16 |
BMR | 76.3 (37.9) | 45.9 (34.7) | 78.5 (70.8) | 46.6 (44.8) | 0.25 |
Hyperaemia | |||||
Pa (mmHg) | 81.2 (17.8) | 90.6 (19.9) | 89.9 (14.1) | 86.2 (17.3) | 0.49 |
Pd (mmHg) | 71.9 (14.9) | 81.6 (19.7) | 80.0 (11.7) | 79.5 (16.0) | 0.44 |
FFR | 0.88 (0.06) | 0.89 (0.08) | 0.89 (0.05) | 0.92 (0.07) | 0.41 |
Tmn (s) | 0.24 (0.10) | 0.20 (0.07) | 0.21 (0.10) | 0.24 (0.17) | 0.71 |
CFR | 4.0 (2.2) | 2.4 (0.8) | 4.6 (4.2) | 2.1 (0.8) | 0.16 |
IMR | 16.3 (10.2) | 15.6 (5.8) | 16.5 (9.7) | 18.8 (14.2) | 0.86 |
CFIP | 0.15 (0, 0.23) | 0.09 (0, 0.21) | 0.12 (0.05, 0.27) | 0.18 (0.06, 0.29) | 0.78 |
RRR | 5.1 (1.9) | 2.9 (1.3) | 5.5 (5.4) | 2.6 (1.2) | 0.13 |
Post Infusion | |||||
Baseline | |||||
Heart rate (bpm) | 63.0 (13.9) | 68.7 (11.9) | 68.8 (8.4) | 66.0 (12.3) | 0.58 |
Systolic BP (mmHg) | 138.3 (22.3) | 140.1 (26.1) | 134.7 (21.5) | 133.0 (23.1) | 0.81 |
Diastolic BP (mmHg) | 63.4 (7.8) | 71.8 (15.3) | 68.3 (13.2) | 64.8 (13.1) | 0.36 |
Pa (mmHg) | 90.8 (16.6) | 89.6 (15.4) | 92.6 (15.3) | 94.9 (8.6) | 0.77 |
Pd (mmHg) | 84.9 (15.9) | 86.4 (16.7) | 88.6 (14.2) | 91.4 (9.0) | 0.65 |
Pd/Pa | 0.93 (0.03) | 0.96 (0.04) | 0.96 (0.04) | 0.96 (0.03) | 0.11 |
Tmn (s) | 0.63 (0.27) | 0.83 (0.41) | 0.66 (0.54) | 0.52 (0.39) | 0.37 |
BMR | 55.4 (30.4) | 66.7 (37.2) | 57.3 (48.5) | 47.8 (38.8) | 0.64 |
Hyperaemia | |||||
Pa (mmHg) | 80.1 (16.7) | 89.6 (15.4) | 90.5 (10.9) | 89.5 (23.9) | 0.38 |
Pd (mmHg) | 71.9 (15.3) | 76.2 (17.1) | 88.6 (14.2) | 82.6 (19.2) | 0.14 |
FFR | 0.89 (0.06) | 0.89 (0.08) | 0.93 (0.03) | 0.93 (0.06) | 0.24 |
Tmn (s) | 0.29 (0.21) | 0.21 (0.07) | 0.25 (0.14) | 0.26 (0.13) | 0.53 |
CFR | 3.0 (2.4) | 4.2 (2.0) | 2.6 (1.5) | 2.1 (1.1) | 0.11 |
IMR | 19.7 (14.6) | 15.0 (6.2) | 20.1 (11.4) | 21.2 (12.2) | 0.49 |
CFIP | 0.17 (0.00, 0.29) | 0.08 (0.00, 0.23) | 0.13 (0.05, 0.29) | 0.19 (0.07, 0.28) | 0.96 |
RRR | 3.61 (2.5) | 4.73 (2.3) | 2.76 (1.6) | 2.46 (1.5) | 0.09 |