Table 1 Inclusion and exclusion criteria

Woman aged > 18 years and < 70 years

Patients with previous history of heart disease or heart failure

First diagnosis of breast cancer at early stages (I, II, III)

Left ventricular dysfunction (left ventricular ejection fraction < 53%) at baseline

Patients who will receive adjuvant or neoadjuvant treatment with curative intention

Metastatic disease

Treatment with anthracyclines and/or anti-HER-2 antibodies (trastuzumab and pertuzumab)

Patients carrying an implantable cardioverter defibrillator

Possibility of completing a cardiac rehabilitation program and programmed visits

Patients with physical or mental limitation to carry out an exercise program

Providing written informed consent

Refuse to participate

Overcome 20% of cardiotoxic treatment