Hypercholesterolaemia (serum total cholesterol before treatment: ≥ 15.5 mmol/L) |
Tendon xanthomata (tendon xanthoma on the dorsal hands, elbows, and knees, or Achilles tendon thickening1) or nodular xanthoma on the skin |
Premature CAD during childhood |
Parents’ family history of heterozygous FH. |
Diagnostic criteria for adult (15 years or older) heterozygous FH by the Japanese FH Management Guideline Criteria |
Hyper- LDL cholesteroalemia (LDL-C before treatment: ≥ 4.7 mmol/L) Tendon xanthomata (tendon xanthoma on the dorsal hands, elbows, and knees, or Achilles tendon thickening) or nodular xanthoma on the skin Family history within the second- degree relatives FH or premature CAD (men <55, women <60 years) |