Table 4 Most common PIMs among home medications

 Drugs that may exacerbate or cause SIADH or hyponatremia (including diuretics, SSRIs, SNRIs, and antipsychotics)

 Scheduled use of PPIs >8 weeks in non-high risk patients

 Benzodiazepines

 Cardiovascular agents that should be avoided or dose reduced due to varying levels of kidney function (including NOACs and potassium sparing diuretics)

 CNS and analgesic agents that should be avoided or dose reduced due to varying levels of kidney function (including duloxetine, gabapentin, pregabalin, and tramadol)

 Combination of opioid analgesics with ≥2 other CNS active agents

 Anticholinergics

 H2 antagonists that should be dose reduced due to varying levels of kidney function

 Digoxin used as first line therapy for atrial fibrillation / flutter or heart failure or dose >0.125 mg/d

 Chronic use of non-cyclooxygenase-selective NSAIDS

 Skeletal muscle relaxants