Bivariate | P value | Multivariable | P value | |
---|---|---|---|---|
HR (95 % CI) | HR 95 % CI | |||
Age (years)a | 1.06 (1.03–1.08) | <0.001 | 1.05 (1.03–1.07) | <0.001 |
Men | 0.82 (0.61–1.1) | 0.19 | 1.1 (0.76–1.5) | 0.74 |
Comorbiditya | ||||
CHADS2 scoreb | 1.7 (1.5–1.9) | <0.001 | 1.5 (1.3–1.7)c | <0.001 |
CHA2DS2-VASc scoreb | 1.5 (1.3–1.6) | <0.001 | 1.4 (1.2–1.6)d | <0.001 |
Charlson Comorbidity Indexb | 1.3 (1.2–1.4) | <0.001 | 1.1 (0.97–1.2)c | 0.14 |
Myocardial infarction | 0.87 (0.54–1.4) | 0.55 | 0.64 (0.39–1.0) | 0.075 |
Heart failure | 1.2 (0.75–1.8) | 0.48 | 0.90 (0.57–1.4) | 0.65 |
Peripheral vascular disease | 1.9 (1.2–2.9) | 0.006 | 1.5 (0.94–2.3) | 0.093 |
Cerebrovascular event | 5.6 (4.1–7.5) | <0.001 | 5.2 (3.8–7.2) | <0.001 |
Dementia | 1.9 (0.93–3.8) | 0.081 | 1.0 (0.48–2.1) | 0.99 |
Chronic pulmonary disease | 0.24 (0.034–1.7) | 0.16 | 0.17 (0.024–1.2) | 0.081 |
History of peptic ulcers | 0.83 (0.46–1.5) | 0.53 | 0.74 (0.41–1.3) | 0.32 |
Liver disease | 1.6 (0.82–3.1) | 0.17 | 1.4 (0.69–2.8) | 0.36 |
Diabetes | 1.2 (0.80–1.7) | 0.44 | 1.3 (0.87–1.9) | 0.21 |
Hemiplegia | 1.6 (0.61–4.4) | 0.32 | 0.63 (0.23–1.8) | 0.38 |
Renal disease | 1.4 (1.2–1.7) | <0.001 | 1.3 (1.1–1.6) | 0.006 |
History of tumours | 1.3 (0.90–2.0) | 0.15 | 1.1 (0.74–1.7) | 0.59 |
Leukaemia | 3.3 (0.46–24) | 0.23 | 3.1 (0.42–23) | 0.27 |
Lymphoma | 0.049 (0.0–2923) | 0.59 | 0.0 (0.0–5.0 × e261) | 0.96 |
Hypertension | 0.98 (0.73–1.3) | 0.92 | 0.94 (0.69–1.3) | 0.69 |
Valve disease | 0.89 (0.53–1.5) | 0.65 | 0.81 (0.48–1.4) | 0.44 |