From: Risk of valvular heart disease associated with use of fenfluramine
Author, year | Duration (months) | "Incident" MR cases | Expected cases | p-value by Poisson | Relative Risk (RR) | Lower 95% CI of RR | Upper 95% CI of RR | z | p-value |
---|---|---|---|---|---|---|---|---|---|
Khan, 1998 | 20.6 | 2.00 | 0.873 | 0.059 | - | - | - | 2.7 | 0.0033 |
Weissman, 1998 | 2.4 | 3.87 | 0.289 | 0.00023 | 14.9 | 5.2 | 42.5 | 5.0 | <0.00001 |
Shively, 1999 | 6.9 | 1.82 | 0.279 | 0.032 | 29.7 | 6.2 | 142.8 | 4.2 | 0.000012 |
Hensrud, 1999 | 9.6 | 0.00 | 0.033 | 0.97 | - | - | - | - | - |
Ryan, 1999 | 16.7 | 1.00 | 0.241 | 0.025 | - | - | - | - | - |
Gardin, 2000 | 11.9 | 8.69 | 0.950 | <0.00001 | 5.0 | 2.4 | 10.4 | 4.3 | <0.00001 |
6 | 8.06 | 0.500 | <0.00001 | 10.5 | 5.3 | 20.5 | 6.8 | <0.00001 | |
Jollis, 2000 | 2 | 0.00 | 0.009 | 0.99 | 0.0 | 0.0 | - | -0.1 | 0.54 |
4.5 | 2.31 | 0.253 | 0.0022 | 9.5 | 3.0 | 30.5 | 3.8 | 0.000079 | |
9 | 5.83 | 0.666 | 0.000069 | 9.1 | 3.9 | 21.1 | 5.1 | <0.00001 | |
18 | 3.28 | 1.018 | 0.020 | 3.3 | 1.0 | 10.8 | 2.0 | 0.022 | |
30 | 0.71 | 0.463 | 0.37 | 1.6 | 0.1 | 17.3 | 0.4 | 0.35 | |
Davidoff, 2001 | 2.5 | 0.96 | 0.120 | 0.11 | 3.6 | 0.5 | 25.3 | 1.3 | 0.096 |
Summary, 2002 | 8.89 | 38.5 | 5.7 | <0.00001 | 5.9 | 4.0 | 8.6 | 9.1 | <0.00001 |